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The Effectiveness of Emergency Room Protocols for Treating Hyperthermia

NCT07433036 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-02-25

No results posted yet for this study

Summary

This study will help us as scientists and clinicians understand how effective commonly used cooling protocols in emergency departments are and which of the protocols is the most effective.

It consists of a single, approximately 1 hour preliminary session and five, approximately 3 hour experimental sessions, equaling an approximate 16 hour total time commitment.

The purpose of this research is to test the effectiveness of three cooling protocols.

1. Cooling packs
2. "Ice Sheets", which are bed sheets soaked in ice water, wrapped around the participant, while a fan blows air on them.
3. Body bag filled with ice, commonly used in emergency departments to treat hyperthermia

Additionally, a negative control (passive cooling in air-conditioned room) and a positive control (cold water immersion).

Conditions

  • Hyperthermia

Interventions

PROCEDURE

Passive cooling

During recovery, participants lie supine in an air-conditioned room

PROCEDURE

Cooling packs

During recovery, participants lie supine while ice packs are applied to both sides of the neck, both arm pits, and both sides of the groin

PROCEDURE

Ice sheets

During recovery, participants are wrapped in bed sheets that have been soaked in ice water, while an electric fan blows air across their body

PROCEDURE

Body bag cooling

During recovery, participants are placed in a body bag full of ice, and then have ice placed on top of their body, followed by zipping the body bag closed.

PROCEDURE

Cold water immersion

During recovery, participants are submerged in a bath, up to their neck, in cold water water with ice

Sponsors & Collaborators

  • University of Colorado, Colorado Springs

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07433036 on ClinicalTrials.gov