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Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest

NCT00391469 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 1359

Last updated 2014-12-02

Study results available
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Summary

The overall goal of this study is to determine whether initiating hypothermia in cardiac arrest patients as soon as possible in the field results in a greater proportion of patients who survive to hospital discharge compared to standard prehospital/field care.

Conditions

  • Out-of-hospital Cardiac Arrest

Interventions

OTHER

Rapid infusion of 2 liters of 4oC normal saline

Patients randomized to mild hypothermia will receive a rapid infusion of 2 liters of 4oC normal saline prior to arrival in the emergency room. Patients randomized to control will receive standard of care following resuscitation from cardiac arrest.

DRUG

Rapid infusion of cold normal saline

Sponsors & Collaborators

  • Medic One Foundation

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Washington

    lead OTHER

Principal Investigators

  • Francis Kim, MD · University of Washington

  • Leonard Cobb, MD · University of Washington

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-12-31
Primary Completion
2013-05-31
Completion
2013-08-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00391469 on ClinicalTrials.gov