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Amygdala Insula Retraining in the Management of Perimenopause Symptoms

NCT07427459 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-06-29

No results posted yet for this study

Summary

The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms.

Our research questions include:

Does AIR reduce overall perimenopausal symptom burden compared to a wait-list control?

Does AIR improve sleep disturbance, vasomotor symptom interference, fatigue, mood, anxiety, and quality of life in perimenopausal individuals?

Are symptom changes associated with improvements in autonomic regulation and sleep parameters, as reflected by exploratory wearable measures including heart rate variability?

Conditions

  • Perimenopause
  • Menopausal Complaints

Interventions

BEHAVIORAL

Amygdala and Insula Retraining (AIR)

Mind-body brain retraining intervention

Sponsors & Collaborators

  • Chronic Conditions Research Fund

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
38 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-15
Primary Completion
2027-01-31
Completion
2027-03-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07427459 on ClinicalTrials.gov