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Cytokine Response to Abdominal Wall Reconstruction

NCT07422584 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2026-02-20

No results posted yet for this study

Summary

This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure.

The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be altered for the purpose of the study and will be determined by the operating surgeon as part of routine clinical decision-making.

Conditions

  • Incisional Ventral Hernia

Interventions

OTHER

Not applicable- observational study

There are no interventions in this observational study.

Sponsors & Collaborators

Principal Investigators

  • Michael Rosen, MD · Northwestern University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-03
Primary Completion
2027-02-05
Completion
2027-03-05

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07422584 on ClinicalTrials.gov