ARTEMIS - The ARTEMIS Cohort

Summary

This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP. The study aims to improve the diagnosis and care of affected children through a comprehensive approach that integrates detailed clinical assessments, brain imaging analyses, and advanced genetic testing. By identifying developmental trajectories, specific impairment profiles, brain MRI patterns, and genetic variants, the researchers aim to elucidate underlying mechanisms, origins and clinical heterogeneity of NPCA. The study also assesses the broader impact of the condition on the quality of life of affected children and the associated burden on their families. Preliminary data found a high prevalence of cognitive and neuropsychiatric impairments, and a frequent lack of identifiable brain lesions on MRI, raising the hypothesis of a strong genetic contribution.

Conditions

• Non-progressive Congenital Ataxia
• Ataxic Cerebral Palsy

Sponsors & Collaborators

• University Hospital, Toulouse

  collaborator OTHER

• Universität Tübingen

  collaborator OTHER

• University Hospital Tuebingen

  collaborator OTHER

• Sykehuset i Vestfold Hospital Trust

  collaborator UNKNOWN

• Aarhus University Hospital

  collaborator OTHER

• KU Leuven

  collaborator OTHER

• Sahlgrenska University Hospital

  collaborator OTHER

• Göteborg University

  collaborator OTHER

• IASO Children's Hospital, Maroussi, Athens, Greece

  collaborator UNKNOWN

• Vastra Gotaland Region

  lead OTHER_GOV

Principal Investigators

• Catherine Arnaud, MD PhD · University Hospital of Toulouse

Eligibility

Min Age

5 Years

Max Age

8 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-15

Primary Completion

2027-06-30

Completion

2027-12-31

Countries

• Belgium
• Denmark
• France
• Germany
• Greece
• Norway
• Sweden

Study Locations