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Salivary Antimicrobial Peptides and Severe Early Childhood Caries in Turkish Children

NCT07414030 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-02-17

No results posted yet for this study

Summary

This observational study aims to evaluate the relationship between salivary antimicrobial peptides and severe early childhood caries (S-ECC) in Turkish children. Severe early childhood caries is a multifactorial disease influenced by microbial, environmental, and host-related factors. Salivary antimicrobial peptides play an important role in the innate immune defense of the oral cavity and may influence susceptibility to dental caries.

In this cross-sectional study, salivary samples were collected from children diagnosed with S-ECC and from caries-free controls. Clinical dental examinations were performed to assess caries status. The levels of selected salivary antimicrobial peptides were measured and compared between groups to determine potential associations.

The findings of this study may contribute to a better understanding of the role of salivary immune components in the development of severe early childhood caries.

Conditions

  • Severe Early Childhood Caries
  • Dental Caries

Sponsors & Collaborators

  • Bezmialem Vakif University

    lead OTHER

Eligibility

Min Age
3 Years
Max Age
6 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2024-09-30
Completion
2024-09-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07414030 on ClinicalTrials.gov