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Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)

NCT07410481 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-04-09

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD.

The main questions it aims to answer are:

Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT?

Participants will:

* Be randomly assigned to receive either AMBET or PCT
* Attend 12 hours of individual psychotherapy sessions over about 12 weeks
* Complete short weekly surveys about their mood and behaviors online
* Wear a Fitbit device to track sleep and activity during the study
* Do brief homework assignments between sessions

Conditions

  • PTSD - Post Traumatic Stress Disorder
  • Cardiac Arrest (CA)

Interventions

BEHAVIORAL

Acceptance and Mindfulness Based Exposure Therapy

Eight sessions of exposure therapy combined with mindfulness delivered via videoconferencing platform. AMBET will consist of 90-minute weekly sessions for 4 weeks, then every other week for 4 more sessions.

BEHAVIORAL

Present-Centered Therapy

Twelve 60-minute weekly sessions of psychotherapy delivered via videoconferencing platform.

Sponsors & Collaborators

Principal Investigators

  • Yuval Neria, PhD · Columbia University

  • Maja Bergman, PhD · Columbia University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
81 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2028-06-30
Completion
2029-03-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07410481 on ClinicalTrials.gov