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Comparison of Allograft, Xenograft and Combined Grafting in Maxillary Sinus Augmentation

NCT07407361 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 37

Last updated 2026-02-12

No results posted yet for this study

Summary

This prospective randomized clinical study evaluates and compares three different grafting approaches (allograft, xenograft, and combined grafting) used in lateral maxillary sinus augmentation prior to dental implant placement.

Patients with posterior maxillary bone deficiency (residual bone height ≤4 mm) undergoing sinus lift surgery were randomly assigned to one of three grafting groups. Cone-beam computed tomography (CBCT) was used to assess bone height before surgery, immediately after grafting, and at 6 months. During implant placement at 6 months, bone biopsy samples were collected from the grafted sites for histological and immunohistochemical evaluation.

The study aims to assess vertical bone gain, graft height stability, and biological bone healing using osteocalcin, osteopontin, and RUNX2 markers. The results are intended to provide clinically relevant information regarding the volumetric and biological behavior of different graft materials used in maxillary sinus augmentation.

Conditions

  • Posterior Maxillary Atrophy
  • Maxillary Sinus Augmentation

Interventions

PROCEDURE

Lateral Maxillary Sinus Augmentation with Allograft

Lateral sinus floor elevation was performed using allograft material prior to dental implant placement.

PROCEDURE

Lateral Maxillary Sinus Augmentation with Xenograft

Lateral sinus floor elevation was performed using xenograft material prior to dental implant placement.

PROCEDURE

Lateral Maxillary Sinus Augmentation with Combined Graft

Lateral sinus floor elevation was performed using a combination of allograft and xenograft materials prior to dental implant placement.

PROCEDURE

Dental Implant Placement Without Sinus Augmentation

Dental implant placement was performed without sinus augmentation. Bone biopsy samples were obtained from the implant site during implant placement for histological and immunohistochemical evaluation.

Sponsors & Collaborators

  • Tokat Gaziosmanpasa University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-30
Primary Completion
2024-04-24
Completion
2024-04-24

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07407361 on ClinicalTrials.gov