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Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

NCT07404852 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 65

Last updated 2026-04-13

No results posted yet for this study

Summary

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

Conditions

  • Large Vessel Occlusion
  • Acute Ischemic Stroke

Interventions

DEVICE

transcutaneous auricular vagal nerve stimulation

Stimulus of the auricular branch of the vagal nerve with the transcutaneous auricular vagal nerve stimulation.

DEVICE

Sham transcutaneous vagal nerve stimulation

Patients assigned to the controls arm will have no electricity applied to the Auricular Branch of the Vagus Nerve.

Sponsors & Collaborators

  • Washington University School of Medicine

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-23
Primary Completion
2027-11-29
Completion
2028-02-29
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07404852 on ClinicalTrials.gov