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The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy

NCT03204968 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 130

Last updated 2017-07-02

No results posted yet for this study

Summary

Systemic inflammation is a potentially debilitating complication of thoracic surgeries that can result in significant physical and economic morbidity for afflicted patients. There is compelling evidence for the role of central nervous system in the regulation of systemic inflammatory responses through humoral mechanisms. Activation of afferent vagus nerve fibers by cytokines triggers anti-inflammatory responses. Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxemia in rats inhibited Tumor necrosis factor (TNF) synthesis in liver preventing the development of shock. The vagal regulatory role of systemic inflammation after lung lobectomy is unknown.

Conditions

  • Inflammatory Response

Interventions

DEVICE

Vagus nerve stimulation

transcutaneous Intermittent stimulation of the vagus nerve using neurostimulator V (Ducest®, Germany)

Sponsors & Collaborators

  • Otto Wagner Hospital

    lead OTHER

Principal Investigators

  • Michael Mueller, MD, PhD · Otto Wagner Hospital

  • Mohamed Salama, MD, PhD · Otto Wagner Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-12-01
Primary Completion
2016-06-05
Completion
2017-06-01

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03204968 on ClinicalTrials.gov