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Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease

NCT07398157 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-05-05

No results posted yet for this study

Summary

The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp.

The main questions it aims to answer are:

* Is there a less invasive method to collect useful brain signals? Find out if these brain signals can be related to movement and/or sleep symptoms.
* How to use these brain signals to tailor adaptive deep brain stimulation settings for movement and/or sleep symptoms

Researchers will compare study derived adaptive DBS settings to subject's clinically programmed continuous DBS settings to see which is better at treating patients PD symptoms.

Conditions

  • PD - Parkinson's Disease

Interventions

DEVICE

Medtronic Percept Deep Brain Stimulation (cDBS)

Using the Percept pulse generator, patients receive clinically-optimized open loop stimulation to the subthalmaic nucleus.

DEVICE

Medtronic Percept Deep Brain Stimulation (daytime aDBS)

Using the Percept pulse generator, patients receive daytime adaptive stimulation to the subthalmaic nucleus.

DEVICE

Medtronic Percept Deep Brain Stimulation (nighttime aDBS)

Using the Percept pulse generator, patients receive nighttime adaptive stimulation to the subthalmaic nucleus.

Sponsors & Collaborators

Principal Investigators

  • Simon Little · University of California, San Francisco

  • Philip Starr · University of California, San Francisco

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-09
Primary Completion
2029-11-30
Completion
2031-11-30
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07398157 on ClinicalTrials.gov