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Cognition and Behavior With Sham Accelerated TMS

NCT07397858 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-07-16

No results posted yet for this study

Summary

The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given.

The main questions this study aims to answer are:

1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule?
2. Do these expectations influence mood, reward processing, or craving?
3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule?

Participants will:

* Complete baseline clinical assessments and an MRI session
* Undergo five days of accelerated sham TMS (no active brain stimulation is delivered)
* Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks

Conditions

Interventions

DEVICE

Transcranial Magnetic Stimulation Sham

All study participants will receive sham TMS (no active stimulation will be provided).

Sponsors & Collaborators

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
15 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-11
Primary Completion
2027-08-31
Completion
2028-01-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07397858 on ClinicalTrials.gov