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Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.

NCT07393490 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 56

Last updated 2026-06-26

No results posted yet for this study

Summary

This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.

Patients undergoing surgical resection of lung cancer often require one-lung ventilation during anaesthesia. This results in alveolar hypoxia accompanied by upregulated expression of inflammatory markers. Apneic oxygenation of the non-ventiladed lung may influence inflammatory processes and oxygenation during surgery. The aim of this study is to evaluate whether apneic oxygenation affects inflammatory markers in lung tissue and postoperative recovery in patients undergoing lung cancer surgery. The study is conducted at a single center and includes adult patients scheduled for elective lung cancer surgery. Data will be collected durig the perioperative period. The results of this study may contribute to improved anaesthetic management and patient outcomes during thoracic surgery.

Conditions

  • Lung Cancer (Diagnosis)

Interventions

PROCEDURE

Apnoeic Oxygenation

Apneic oxygenation of the non-ventilated lung is applied during lung cancer surgery to maintain oxygenation and decrease inflammatory response while the lung is not mechanically ventilated.

PROCEDURE

Standard Ventilation

Standard ventilation is applied during lung cancer surgery according to routine clinical practice.

Sponsors & Collaborators

  • Osijek University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-02
Primary Completion
2026-08-31
Completion
2026-09-30

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07393490 on ClinicalTrials.gov