Upadacitinib Versus IL-17 Inhibitors in Patients With Psoriatic Arthritis
NCT07386717 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70
Last updated 2026-02-04
Summary
Psoriatic arthritis (PsA) is a chronic inflammatory disease with heterogeneous musculoskeletal and dermatologic manifestations, leading to significant functional impairment and reduced quality of life. Although targeted therapies such as Janus kinase inhibitors and interleukin-17 inhibitors have demonstrated efficacy in randomized controlled trials, real-world comparative evidence between these treatment strategies remains limited.
This observational cohort study aims to compare the real-world effectiveness and safety of upadacitinib and interleukin-17 inhibitors in patients with PsA over a 24-week follow-up period. By evaluating clinical outcomes under routine clinical practice conditions, this study seeks to provide evidence to support individualized treatment selection in PsA management.
Conditions
- Psoriatic Arthritis
- Upadacitinib
- Interleukin-17 Inhibitors
Sponsors & Collaborators
-
Peking University First Hospital
lead OTHER
Eligibility
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-01-01
- Primary Completion
- 2025-12-31
- Completion
- 2025-12-31
Countries
- China
Study Locations
More Related Trials
-
A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone
NCT02675426 ·Status: COMPLETED ·Phase: PHASE3
-
An Observational Study to Assess the Real-World Effectiveness of Upadacitinib in Adult Participants With Rheumatoid Arthritis
NCT05170646 ·Status: COMPLETED
-
Tapering of Biologics in Inflammatory Arthritis Patients in Remission
NCT04429776 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs
NCT03086343 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis
NCT03725007 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis
NCT04169373 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis (RA) Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDs
NCT02720523 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
To Evaluate the Efficacy and Safety of SHR0302 Tablet in Subjects of Active Psoriatic Arthritis
NCT04957550 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy And Safety Of Tofacitinib In Chinese Subjects With Active Psoriatic Arthritis
NCT03486457 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis
NCT04497597 ·Status: COMPLETED
-
A Study of the Safety and Effectiveness of Ustekinumab in Patients With Psoriatic Arthritis
NCT01009086 ·Status: COMPLETED ·Phase: PHASE3
-
Certolizumab Pegol in Subjects With Adult Onset Active and Progressive Psoriatic Arthritis
NCT01087788 ·Status: COMPLETED ·Phase: PHASE3
-
Rheumatoid Arthritis Satisfaction Outcome Research
NCT03703817 ·Status: COMPLETED
-
Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severely Active Psoriatic Arthritis Subjects With Inadequate Response to Disease Modifying Anti-Rheumatic Drug Therapy
NCT00646178 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of IL17 Inhibitor in Comparison With Anti-TNF in Patients With Ankylosing Spondylitis
NCT06642207 ·Status: RECRUITING
-
Interleukin-17 (IL-17) Inhibitor in Combination With Tumor Necrosis Factor α (TNFα )Inhibitor for the Treatment of Ankylosing Spondylitis
NCT06833112 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Real-world Effectiveness of Adalimumab on Health Outcomes in Chinese Patients With Immune-Mediated Inflammatory Diseases
NCT03339089 ·Status: COMPLETED
-
Efficacy and Safety of Ivarmacitinib in the Treatment of Patients With Polymyalgia Rheumatica
NCT07266168 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Monocyte Chemoattractant Protein-1 in Psoriatic Arthritis Patients
NCT05637905 ·Status: UNKNOWN
-
IL17 Rate and Spondyloarthritis
NCT05592574 ·Status: RECRUITING
-
A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis
NCT06454188 ·Status: RECRUITING ·Phase: PHASE4
-
A Study Investigating the Efficacy and Safety of Upadacitinib (ABT-494) Given With Methotrexate (MTX) in Adults With Rheumatoid Arthritis Who Have Had an Inadequate Response to MTX Alone
NCT02066389 ·Status: COMPLETED ·Phase: PHASE2
-
Early Changes in Pain, Disease Activity, and Ultrasound Evidence of Inflammatory Synovitis in Patients Receiving JAK-inhibitor vs. TNF-inhibitor Therapy for Active Rheumatoid Arthritis: A Feasibility Study.
NCT05153200 ·Status: UNKNOWN ·Phase: PHASE4
-
A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice
NCT05049798 ·Status: ACTIVE_NOT_RECRUITING
-
A Study of the Safety and Effectiveness of Lyophilized Certolizumab Pegol in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis
NCT00175877 ·Status: COMPLETED ·Phase: PHASE3