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geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

NCT07380906 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1200

Last updated 2026-05-22

No results posted yet for this study

Summary

The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older with symptomatic KOA that has not responded to medical therapy.

The main questions it aims to answer are:

1. Does GAE lead to sustained improvement in pain (WOMAC, VAS) and quality-of-life scores over 12-36 months?
2. What patient or procedural factors are associated with better outcomes after GAE?

Participants will:

* Undergo GAE as part of their routine clinical care.
* Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires.
* Have safety outcomes tracked according to Society of Interventional Radiology guidelines.

There is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.

Conditions

  • Knee Osteoarthristis

Interventions

PROCEDURE

Genicular Artery Embolization

Genicular Artery Embolization (GAE) is a minimally invasive, image-guided procedure in which embolic agents are delivered into hyperemic genicular arteries to reduce synovial inflammation and knee pain from osteoarthritis.

Sponsors & Collaborators

  • Joint & Vascular Institute

    lead INDUSTRY

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-16
Primary Completion
2030-04-30
Completion
2030-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07380906 on ClinicalTrials.gov