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Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

NCT05700682 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-08-07

No results posted yet for this study

Summary

In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.

Conditions

  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Osteo Arthritis Shoulders
  • Synovitis of Knee
  • Synovitis/Tenosynovitis - Hip
  • Synovitis
  • Pain, Chronic

Interventions

DEVICE

Shoulder/Hip/Knee Embolization with Embozene Microspheres

Fluoroscopically-guided arterial embolization of synovitis in the painful shoulder, hip or knee.

Sponsors & Collaborators

  • Varian Medical Systems

    collaborator INDUSTRY

  • Palo Alto Veterans Institute for Research

    lead OTHER

Principal Investigators

  • Sirish Kishore, MD · VA Palo Alto Health Care System

Eligibility

Min Age
25 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-15
Primary Completion
2026-03-01
Completion
2026-08-01
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05700682 on ClinicalTrials.gov