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Effect of Rutin on Inflammation Pathways in Ulcerative Colitis Patients

NCT07370220 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-01-27

No results posted yet for this study

Summary

This study evaluates the therapeutic role of Rutin (a plant-derived flavonoid) in reducing the severity of Ulcerative Colitis (UC). The study investigates whether Rutin can decrease intestinal inflammation and improve clinical symptoms by inhibiting the NLRP3 inflammasome signaling pathway, which is activated by oxidative stress in the colon.

Conditions

Interventions

DRUG

Rutin 500 MG Oral Tablet

Oral capsules twice daily for 30 days

DIAGNOSTIC_TEST

Fecal Calprotectin

Sample collection only for baseline comparison.

DRUG

Placebo

Placebo tablets for 30 days

Sponsors & Collaborators

  • Benha University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-22
Primary Completion
2025-05-25
Completion
2025-11-15

Countries

  • Egypt

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07370220 on ClinicalTrials.gov