Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study

Summary

The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module.

The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies.

The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.

Conditions

• Rheumatoid Arthritis
• Atherosclerotic Ischemic Disease
• Pulmonary Disease
• Depressive Disorder
• Anxiety Disorders
• Cardiovascular and Respiratory Disease
• Cardiovascular Biomarkers
• Cardiovascular (CV) Risk
• Cardiovascular Disease
• Cardiovascular Disease (CKD)
• Cardiovascular Disease (CVD) Risk Factors
• COPD (Chronic Obstructive Pulmonary Disease)
• Pulmonary Diseases or Conditions
• Pulmonary Disease, Chronic Obstructive
• Depressive and Anxiety Disorders
• Interstitial Lung Disease in Patients With Rheumatoid Arthritis
• Lung Cancer (Diagnosis)

Sponsors & Collaborators

• University of Aarhus

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Independent Research Fund Denmark

  collaborator INDUSTRY

• Alfasigma S.p.A.

  collaborator INDUSTRY

• ATACC-RD consortium

  collaborator UNKNOWN

• The Danish Rheumatism Association

  collaborator OTHER

• Ellen Margrethe Hauge

  lead OTHER

Principal Investigators

• Ellen-Margrethe Hauge, MD, PhD · Aarhus University Hospital and Aarhus University

• Dzenan Masic, MD, PhD · Aarhus University Hospital and Aarhus University

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-02-21

Primary Completion

2038-12-31

Completion

2040-12-31

Countries

• Denmark

Study Locations