A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA
NCT07362667 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 44
Last updated 2026-01-23
Summary
To evaluate the efficacy and safety of bronchoscopic airway clearance and amphotericin B spraying in the treatment of allergic bronchopulmonary aspergillosis
Conditions
- ABPA
- Allergic Bronchopulmonary Aspergillosis
- Allergic Bronchopulmonary Aspergillosis (ABPA)
- Airway Clearance
- Mucus Plug
- Amphotericin B
- Bronchoscope
Interventions
- PROCEDURE
-
The patients were treated with bronchoscopic airway clearance and amphotericin B spraying
In addition to standard medical therapy (oral glucocorticoids with or without oral antifungal agents), bronchoscopic airway clearance and bronchoscopic spraying of amphotericin B (depending on the effectiveness of bronchoscopic mucus plug removal, At least one time of bronchoscopic airway clearance and amphotericin B spraying). The previous treatment for bronchial asthma was maintained, including inhaled corticosteroids + long-acting β-receptor agonists, leukotriene receptor antagonists, etc.
Sponsors & Collaborators
-
Qianfoshan Hospital
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-01-10
- Primary Completion
- 2028-12-31
- Completion
- 2028-12-31
Countries
- China
Study Locations
More Related Trials
-
Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis
NCT02714283 ·Status: COMPLETED
-
Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa
NCT03715322 ·Status: UNKNOWN ·Phase: PHASE3
-
Safety, Tolerability and Efficacy of S-1226 in Cystic Fibrosis and Non CF Bronchiectasis
NCT03903913 ·Status: UNKNOWN ·Phase: PHASE2
-
Long-term Impact of Inhaled Tobramycin for Pseudomonas Aeruginosa Eradication in Bronchiectasis (ERASE II)
NCT06760273 ·Status: RECRUITING
-
Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis
NCT02081963 ·Status: COMPLETED ·Phase: PHASE4
-
Nebulized Bacteriophage Therapy in Cystic Fibrosis Patients With Chronic Pseudomonas Aeruginosa Pulmonary Infection
NCT05010577 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Prevention of Recurrence With Cordyceps Sinensis in Mycobacterium Avium Complex Pulmonary Disease
NCT07174076 ·Status: RECRUITING ·Phase: PHASE4
-
Dose Range Finding, Efficacy, and Safety Study of Nebulized CSL787 in Adults With Non-cystic Fibrosis Bronchiectasis (NCFB)
NCT07048262 ·Status: RECRUITING ·Phase: PHASE2
-
Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
NCT02096315 ·Status: TERMINATED ·Phase: PHASE2
-
Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis
NCT06093191 ·Status: COMPLETED ·Phase: PHASE4
-
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
NCT00769119 ·Status: COMPLETED ·Phase: PHASE2
-
Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis
NCT00669331 ·Status: COMPLETED ·Phase: PHASE3
-
Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
NCT03449459 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Study to Evaluate Itraconazole Administered as Inhaled Dry Powder in Adults With Asthma and ABPA
NCT05667662 ·Status: TERMINATED ·Phase: PHASE2
-
Nebulised RESP30X Nitric Oxide Formulations in NCFB Patients With Pseudomonas Aeruginosa (Pa)
NCT06663176 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Recombinant Interleukin-7 (CYT107) to Treat Patients With Refractory Nontuberculous Mycobacterial Lung Disease
NCT04154826 ·Status: TERMINATED ·Phase: PHASE2
-
Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis
NCT02392663 ·Status: COMPLETED ·Phase: NA
-
Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis
NCT03960606 ·Status: TERMINATED ·Phase: PHASE2
-
Ph 1/2 Study Evaluating Safety and Tolerability of Inhaled AP-PA02 in Subjects With Chronic Pseudomonas Aeruginosa Lung Infections and Cystic Fibrosis
NCT04596319 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
High Dose Inhaled Mannitol Study
NCT01076491 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection
NCT06016088 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Study to Assess CSL787 in Non-cystic Fibrosis Bronchiectasis (NCFB)
NCT04643587 ·Status: COMPLETED ·Phase: PHASE1
-
Inhaled Molgramostim in Pediatric Participants With Autoimmune Pulmonary Alveolar Proteinosis (aPAP).
NCT06431776 ·Status: RECRUITING ·Phase: PHASE3
-
A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device
NCT00730977 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Hypertonic Saline Inhalation for Mycobacterium Avium Complex Pulmonary Disease
NCT05192057 ·Status: RECRUITING ·Phase: PHASE4