Nebulised RESP30X Nitric Oxide Formulations in NCFB Patients With Pseudomonas Aeruginosa (Pa)
NCT06663176 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2026-03-10
Summary
A Phase 1/2a, Multi-Centre, Randomised, Open-label study to assess the safety, tolerability, PK, and efficacy of RESP30X in Adult NCFB participants with confirmed high-titre respiratory PPMs.
Conditions
- Non-Cystic Fibrosis Bronchiectasis
Interventions
- DRUG
-
RESP302
Nitric Oxide agent
- DRUG
-
RESP303
Nitric Oxide agent
Sponsors & Collaborators
-
Thirty Respiratory Limited
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-10-16
- Primary Completion
- 2028-02-05
- Completion
- 2028-05-05
Countries
- Ukraine
Study Locations
More Related Trials
-
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
NCT00769119 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis
NCT01314716 ·Status: COMPLETED ·Phase: PHASE3
-
Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa
NCT03715322 ·Status: UNKNOWN ·Phase: PHASE3
-
Study Evaluating Fosfomycin/Tobramycin for Inhalation in Cystic Fibrosis Patients With Pseudomonas Aeruginosa Lung Infection
NCT00794586 ·Status: COMPLETED ·Phase: PHASE2
-
Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis
NCT02081963 ·Status: COMPLETED ·Phase: PHASE4
-
Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis
NCT01313624 ·Status: COMPLETED ·Phase: PHASE3
-
Ciprofloxacin Dry Powder for Inhalation (DPI) in Non-cystic Fibrosis Bronchiectasis (Non-CF BE)
NCT02106832 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis
NCT00205647 ·Status: COMPLETED ·Phase: PHASE2
-
Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis
NCT02714283 ·Status: COMPLETED
-
Ph 1/2 Study Evaluating Safety and Tolerability of Inhaled AP-PA02 in Subjects With Chronic Pseudomonas Aeruginosa Lung Infections and Cystic Fibrosis
NCT04596319 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis
NCT06093191 ·Status: COMPLETED ·Phase: PHASE4
-
Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
NCT03449459 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis
NCT00255983 ·Status: TERMINATED ·Phase: PHASE3
-
Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis
NCT00930982 ·Status: COMPLETED ·Phase: PHASE2
-
Exhaled Breath Aerosol for the Etiological Diagnosis of Respiratory Tract Infections: a Pilot Study
NCT06229613 ·Status: COMPLETED
-
The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2
NCT04313023 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of AG2001 in Patients With Acute Bronchitis
NCT07198347 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Study With Phage for CF Subjects With Pseudomonas Lung Infection
NCT06998043 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety Study of AeroVanc for the Treatment of Persistent MRSA Lung Infection in Cystic Fibrosis Patients
NCT01746095 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate Arikace™ in CF Patients With Chronic Infection Due to Pseudomonas Aeruginosa
NCT01315691 ·Status: WITHDRAWN ·Phase: PHASE3
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects
NCT02058407 ·Status: TERMINATED ·Phase: PHASE1
-
Treatment of Respiratory Tract Infection and/or Acute Bronchitis With Ectoin Inhalation Solution
NCT02632851 ·Status: COMPLETED
-
Efficacy and Safety of 28 or 56 Day Treatment for Pseudomonas Aeruginosa in Children With Cystic Fibrosis
NCT00391976 ·Status: COMPLETED ·Phase: PHASE3
-
Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium.
NCT03460704 ·Status: TERMINATED ·Phase: PHASE3
-
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
NCT05986318 ·Status: RECRUITING ·Phase: PHASE2