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Peri-Implant Sulcus Fluid Stress Markers in Health and Disease

NCT07353515 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2026-01-20

No results posted yet for this study

Summary

This study examines the association between psychosocial stress and peri-implant diseases. Peri-implant diseases are inflammatory conditions affecting the tissues around dental implants and may contribute to implant failure. Stress-related hormones, including cortisol and dehydroepiandrosterone (DHEA), may influence inflammatory responses in peri-implant tissues.

In this study, peri-implant sulcular fluid samples are collected from patients with peri-implant health, peri-implant mucositis, and peri-implantitis. Levels of cortisol, DHEA, and interleukin-6 (IL-6) are analyzed. Anxiety and depression levels are assessed using standardized questionnaires, and clinical peri-implant parameters are recorded.

The purpose of this study is to evaluate the relationship between stress-related biomarkers, psychological status, and peri-implant health and disease.

Conditions

  • Peri-implantitis
  • Peri-implant Mucositis
  • Peri-Implant Health

Interventions

DIAGNOSTIC_TEST

Psychological Assessment

Psychological status was evaluated using the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI).

DIAGNOSTIC_TEST

Peri-implant Sulcular Fluid Biomarker Analysis

Peri-implant sulcular fluid samples were collected and analyzed for cortisol, dehydroepiandrosterone (DHEA), and interleukin-6 (IL-6) levels using enzyme-linked immunosorbent assay (ELISA).

DIAGNOSTIC_TEST

Peri-implant Clinical Examination

Clinical peri-implant parameters including plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level, and keratinized tissue width were recorded using a periodontal probe.

DIAGNOSTIC_TEST

Radiographic Assessment

Marginal bone levels around dental implants were assessed using standardized periapical radiographs.

Sponsors & Collaborators

  • Inonu University

    lead OTHER

Principal Investigators

  • Vesile E Toy, PhD · Inonu University, Department of Periodontology Faculty of Dentistry

  • Furkan Kuşoğlu, DDS · Inonu University, Department of Periodontology Faculty of Dentistry

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-15
Primary Completion
2023-12-15
Completion
2024-06-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07353515 on ClinicalTrials.gov