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Repeated Injections of i-PRF for Decreasing Root Resorption After the Orthodontic Treatment.

NCT07352241 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-01-20

No results posted yet for this study

Summary

Mandibular incisor crowding is a frequent issue that prompts many adults to seek orthodontic treatment. The treatment may enhance patients' quality of life, facilitate dental plaque control, and improve the quality of periodontal tissue. However, this treatment is accompanied by several side effects, including resorption of the apical portion of the teeth. Platelet-rich concentrates, such as injectable platelet-rich fibrin, have been shown to have positive effects on both soft- and hard-tissue healing. They may serve as a beneficial self-derived material to prevent this complication.

Conditions

  • Crowding of Anterior Maxillary Teeth

Interventions

PROCEDURE

4-time i-PRF injection group

I-PRF will be injected in 4 sessions at 28-day intervals. The injection will administered submucosally in the buccal region of the lower incisors, using 2 ml of i-PRF per session (0.5 ml per incisor). Orthodontic wires will be sequenced until they reach 0.019×0.025-inch stainless steel.

PROCEDURE

Saline injection

Saline serum will be injected in 4 sessions at 28-day intervals. The injection will be administered submucosally in the buccal region of the lower incisors, using 2 ml of i-PRF per session (0.5 ml per incisor). Orthodontic wires will be sequenced until they reach 0.019×0.025-inch stainless steel.

Sponsors & Collaborators

  • Damascus University

    lead OTHER

Principal Investigators

  • Mohammad I. Idris, DDS · Faculty of Dentistry, University of Damascus

  • Ahmad S. Burhan, DDS MSc PhD · Faculty of Dentistry, University of Damascus

  • Mohammad Y Hajeer, DDS MSc PhD · Faculty of Dentistry, University of Damascus

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
17 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-13
Primary Completion
2024-09-11
Completion
2025-08-04

Countries

  • Syria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07352241 on ClinicalTrials.gov