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Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty

NCT07350252 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2026-05-08

No results posted yet for this study

Summary

The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.

Conditions

  • Osteo Arthritis of the Knee

Interventions

DRUG

Ropivacain 5 mg/ml + Clonidine

Drug used in the block

Sponsors & Collaborators

  • Greta and Johan Kock Foundation

    collaborator UNKNOWN

  • Region Skane

    lead OTHER

Principal Investigators

  • Andreas Ekman, MD, PhD · VO Planned Operations, Trelleborg Hospital, and Lund University, Sweden

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-05
Primary Completion
2027-03-01
Completion
2027-09-01

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07350252 on ClinicalTrials.gov