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Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues

NCT07348224 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-04-29

No results posted yet for this study

Summary

Electronic cigarettes are battery-operated devices that can produce an aerosol by heating a liquid which commonly contains nicotine. In recent years, products containing synthetically produced nicotine and nicotine analogues have entered the market. However, it remains unclear whether these types of nicotine have the same effects as conventional nicotine derived from the tobacco plant. The aim of this study is to investigate the effects of these nicotine types and to gain a better understanding of their respective mechanisms of action.

Conditions

  • Nicotine
  • Vaping
  • Synthetic Nicotine
  • Nicotine Analogues

Interventions

OTHER

Vaping of synthetic S-nicotine

Vaping of e-liquids containing synthetic S-nicotine

OTHER

Vaping of racemic nicotine (S-/R-nicotine)

Vaping of e-liquids containing synthetic racemic nicotine (S-/R-nicotine)

OTHER

Vaping of 6-methylnicotine

Vaping of e-liquids containing the nicotine analogue 6-methylnicotine (6MN)

Sponsors & Collaborators

  • Swiss Tobacco Prevention Funds

    collaborator UNKNOWN

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07348224 on ClinicalTrials.gov