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Examining the Effectiveness of Single-Limb Exercise Training for COPD Patients During Exacerbation Periods

NCT07348003 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-01-16

No results posted yet for this study

Summary

Resistance exercise applications during acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are employed to enhance functional capacity and prevent muscle atrophy by increasing muscle strength.

Owing to the limited cardiorespiratory reserve of COPD patients, single-limb exercises are better tolerated compared to traditional bilateral exercises. A study conducted by Vogiatzis et al. (2009) indicated that single-leg exercises require lower ventilation and result in more efficient oxygen consumption than bilateral exercises. This physiological advantage may be effective in reducing muscle weakness by increasing exercise endurance in COPD patients with restricted respiratory capacity.

The present study aims to demonstrate that single-limb resistance exercise is an effective rehabilitation method for increasing functional exercise capacity in patients during COPD exacerbations compared to a control group. Furthermore, the therapeutic effects of single-limb resistance exercises on dyspnea perception, fatigue, anxiety, and depression will be established. The study will also show that these exercises are both feasible and safe within rehabilitation protocols during the exacerbation period.

Conditions

  • Chronic Obstructive Airways Disease Exacerbated

Interventions

OTHER

Single Limb Exercise Training

Participants will perform unilateral resistance exercises for six major muscle groups (shoulder flex/abd, elbow flex, hip flex, knee flex/ext) using free weights in a seated position. The intensity is set at 50-70% of 1RM, consisting of 2 sets of 8 repetitions per limb. This 8-week program will be conducted twice weekly as an adjunct to routine hospital physiotherapy and standard inpatient physiotherapy, including breathing retraining (diaphragmatic and pursed-lip breathing) and thoracic expansion exercises.

OTHER

Routine Exercise

Physiotherapy Intervention: Just standard inpatient physiotherapy, including breathing retraining (diaphragmatic and pursed-lip breathing) and thoracic expansion exercises.

Sponsors & Collaborators

  • Alper Kemal Gürbüz

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-02
Primary Completion
2026-08-01
Completion
2027-09-25

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07348003 on ClinicalTrials.gov