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Environment, Pathogens, and Host Interactions in Melioidosis

NCT07345910 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 2400

Last updated 2026-01-16

No results posted yet for this study

Summary

This is a longitudinal, multicentre observational study conducted across three established microbiology units integrated within hospital and community health systems in Thailand, Lao PDR, and Cambodia.

The hospital cohort will enroll approximately1,000 patients with positive melioidosis. Participants will be followed at six time points from admission through one year (post-discharge) to capture acute and recovery-phase outcomes, with clinical data collected on demographics, comorbidities, exposures, treatment, adherence, and outcomes.

For each confirmed case, a healthy control will be recruited within two weeks and matched by age, sex, and village of residence. Controls with no symptoms or history of melioidosis will provide a single blood sample at enrolment and will be followed by telephone at 6 and 12 months.

In addition to hospital-based surveillance, a high-risk community in northern Ubon Ratchathani-referred to as the Sandbox Village-will be intensively monitored to capture subclinical infections and to assess environmental factors influencing disease acquisition.

This study is funded by the Wellcome Trust. The grant reference number is 323077/Z/24/Z

Conditions

  • Melioidosis

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Kamolchanok Claire Chewapreecha, PhD · Mahidol Oxford Tropical Research Unit

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2034-12-01
Completion
2034-12-01

Countries

  • Cambodia
  • Laos
  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07345910 on ClinicalTrials.gov