MedTrace Logo

The Microbiology of Pleural Infection

NCT04569110 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 251

Last updated 2020-10-01

No results posted yet for this study

Summary

Pleural Infection (PI) is a common, severe and complicated disease with considerable morbidity and mortality. (1,2) The knowledge of pleural infection microbiology remains incomplete. Sequencing of the bacterial 16S rRNA gene is a reliable methodology to discover the total microbiome of complex samples.

The investigators designed a translational metagenomics study to study the bacteriology of pleural infection. The investigators will use pleural fluid specimens from a) the "Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study" (3) clinical trial and b) non-pleural infection patients. The pleural fluid specimens will be subjected to 16S rRNA next generation sequencing.

Conditions

  • Pleural Infection
  • Pleural Infection Bacterial

Interventions

OTHER

Not applicable. Observational study. Retrospective analysis of samples.

Not applicable. Observational study. Retrospective analysis of samples.

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-10
Primary Completion
2020-06-30
Completion
2020-08-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04569110 on ClinicalTrials.gov