Neuroimaging of Adolescent Cannabis Use Treatment

Summary

This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.

Conditions

• Cannabis Use
• Cannabis Dependence
• Cannabis Use Disorder
• Cannabis Abuse
• Cannabis Intoxication
• Cannabis Smoking
• Cannabis Withdrawal
• Cannabis-Related Disorder
• Cannabis Abuse, in Remission
• Cannabis Abuse, Episodic Use
• Marijuana
• Marijuana Abuse
• Marijuana Use
• Marijuana Smoking
• Marijuana Dependence
• Marijuana User
• Marijuana-Related Disorder
• Marijuana Use Disorder
• Addiction
• Addiction, Substance
• Substance Use
• Substance Use Disorders
• Substance Dependence
• Substance Abuse
• Substance Related Problem
• Substance Abuse Drug Chronic

Interventions

BEHAVIORAL

Contingency Management

Contingency management is an evidence-based behavioral intervention used to treat substance use disorders, including cannabis use disorder (CUD). Contingency management operates on the principles of instrumental learning, where positive reinforcement is used to encourage desired behaviors, such as abstinence from cannabis. First, specific target behaviors are identified for reinforcement. In CUD, this is often abstinence from cannabis use, verified through regular urine drug screens and self-reports. If the target behavior (i.e., abstaining from cannabis for a specified time period) is achieved, then patients receive tangible rewards immediately after attaining the target behavior. These rewards are often in the form of money, vouchers, or other incentives that are meaningful to the individual. We will examine whether success during contingency management treatment for cannabis use is associated with neural activity during instrumental learning in N=80 adolescents ages 14-17.

DEVICE

Elastic Net Regression

We will apply an elastic net regression model to the neuroimaging data to estimate CUDIT score based on neuroimaging data.

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Indiana University

  lead OTHER

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

14 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-06-30

Primary Completion

2030-05-31

Completion

2030-05-31

FDA Device

Yes

Countries

• United States

Study Locations