MedTrace Logo

Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy

NCT07309991 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 2500

Last updated 2026-06-16

No results posted yet for this study

Summary

This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.

Conditions

  • Esophageal Carcinoma
  • Esophageal Adenocarcinoma
  • Esophagectomy
  • PaO2
  • Esophageal Anastomotic Leakeage

Sponsors & Collaborators

  • Sichuan Cancer Hospital and Research Institute

    collaborator OTHER

  • Affiliated Hospital of North Sichuan Medical College

    collaborator OTHER

  • Hebei Medical University Fourth Hospital

    collaborator OTHER

  • Affiliated Cancer Hospital of Shantou University Medical College

    collaborator OTHER

  • Shanghai Chest Hospital

    collaborator OTHER

  • Sun Yat-sen University

    lead OTHER

Principal Investigators

  • Hong Yang, M.D. · Department of Thoracic Surgery, Sun Yat-sen University Cancer Center

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2025-12-01
Completion
2026-12-01

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07309991 on ClinicalTrials.gov