MedTrace Logo

Establishing a Controlled Human Infection Model for Influenza H3N2 as a Foundation for Pandemic Preparedness

NCT07305207 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2025-12-26

No results posted yet for this study

Summary

The overall objective is to establish an influenza Controlled Human Infection Model (CHIM) in Canada that can be used to assess the safety and efficacy of candidate vaccines, biologics, and therapeutics targeting influenza viruses.

Conditions

  • Influenza (Healthy Volunteers)

Interventions

BIOLOGICAL

Intranasal inoculation of RG-A/Texas/71/2017 (H3N2) influenza in each naris on Day 1 of the study.

Participants will be inoculated intranasally with a single dose of the A/H3N2 challenge virus or placebo

Sponsors & Collaborators

  • Canadian Center for Vaccinology

    collaborator OTHER

  • McGill University Health Centre/Research Institute of the McGill University Health Centre

    collaborator OTHER

  • Dalhousie University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2027-06-01
Completion
2028-01-31

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07305207 on ClinicalTrials.gov