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Functional MRI for Monitoring Progression and Assessing Trends in ILD

NCT07300696 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-12-24

No results posted yet for this study

Summary

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:

Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.

Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.

Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Conditions

  • Interstitial Lung Diseases (ILD)

Interventions

DIAGNOSTIC_TEST

Lung MRI Protocol with Functional and Contrast-Enhanced Sequences

Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.

Sponsors & Collaborators

  • German Center for Lung Research

    collaborator OTHER

  • Thoraxklinik-Heidelberg gGmbH

    collaborator OTHER

  • University Hospital Schleswig-Holstein

    collaborator OTHER

  • University Hospital Heidelberg

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-20
Primary Completion
2027-02-28
Completion
2027-07-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07300696 on ClinicalTrials.gov