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Image-Based Structural and Functional Phenotyping of the COSYCONET Cohort Using MRI and CT

NCT02629432 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 602

Last updated 2017-05-11

No results posted yet for this study

Summary

The main objective of this trial is to prove that MRI - as the imaging modality without the use of ionizing radiation - can replace CT for structural and functional regional phenotyping of COPD. The identification of different COPD phenotypes, such as the "emphysema-type" and the "airway-type", is important because therapy and prognosis will be different. The medical problem addressed in this trial is the image-based phenotyping of COPD. The sensitivity and specificity of MRI will be compared to Lowdose-CT serving as the gold standard. MRI and CT of the lung will be performed in a multi-centre cohort of 625 COPD-patients from the main COSYCONET cohort. The reliability of the MRI results will be demonstrated. MRI phenotypes will be evaluated visually and using software with quantitative read-outs. The agreement of both will be determined. The additional information of MRI over CT will be assessed.

Conditions

  • Chronic Obstructive Pulmonary Disease (COPD)

Sponsors & Collaborators

  • Philipps University Marburg

    collaborator OTHER

  • Hannover Medical School

    collaborator OTHER

  • University Hospital Heidelberg

    lead OTHER

Principal Investigators

  • Juergen Biederer, Professor · University Hospital Heidelberg

  • Bertram Jobst, Dr. · University Hospital Heidelberg

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2016-07-31
Completion
2016-07-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02629432 on ClinicalTrials.gov