MedTrace Logo

Menthol for Improving Movement and Sleep in Parkinson's Disease Patients

NCT07294469 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-01-08

No results posted yet for this study

Summary

Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.

Conditions

Interventions

DRUG

Menthol gloves and socks

Participants will wear menthol-containing gloves and socks for five minutes per day, five days a week, over a four-week period.

DRUG

Placebo gloves and socks

Participants will wear gloves and socks with plain lotion for five minutes per day, five days a week, over a four-week period.

Sponsors & Collaborators

  • China Medical University, Taiwan

    collaborator OTHER

  • Taipei Medical University Hospital

    lead OTHER

Principal Investigators

  • Yi-Hung Chen, PhD · International Master Program in Integrative Health, College of Chinese Medicine, China Medical University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-15
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • Taiwan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07294469 on ClinicalTrials.gov