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Sarcopenia and NMIBC Prognosis Study

NCT07285408 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2025-12-16

No results posted yet for this study

Summary

The goal of this observational study is to evaluate whether body composition abnormalities (sarcopenia, myosteatosis, and obesity) and nutritional status influence the risk of recurrence and progression in adult patients with non-muscle-invasive bladder cancer (NMIBC). The main questions it aims to answer are:

Do sarcopenia, myosteatosis, obesity, or malnutrition increase the likelihood of NMIBC recurrence and progression?

Can clinical, laboratory, and CT-derived body composition parameters serve as predictive biomarkers that improve individualized risk stratification?

Participants will undergo routine clinical and radiologic assessments, including:

* completion of the SARC-F and NRS nutritional screening questionnaires
* anthropometric measurements (BMI, waist circumference)
* laboratory evaluation including serum albumin and testosterone
* CT-based assessment of skeletal muscle index (SMI) and muscle density (SMD)
* standard TURBT and structured follow-up with cystoscopy, cytology, imaging, and clinical evaluations to document recurrence and progression.

Conditions

  • Bladder Cancer Cell Transitional

Sponsors & Collaborators

  • General Hospital Sveti Duh

    lead OTHER

Principal Investigators

  • Adelina Hrkac, MD · Klinička bolnica "Sveti Duh", Zavod za urologiju

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-02
Primary Completion
2027-07-12
Completion
2029-07-09

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07285408 on ClinicalTrials.gov