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Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus

NCT07281040 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2025-12-15

No results posted yet for this study

Summary

Aims and Objectives

1. Choose which adjunctive therapies, at what dose, and for how long
2. Choose the dose(s) of IV furosemide to be used as the comparator
3. Choose primary and secondary outcomes
4. Estimate recruitment and engage sites for a future trial

Work package 2a methods overview

1. An online survey of clinicians (doctors, nurses and pharmacists) assessing potential ability to recruit and the acceptability of each adjunct and willingness to support a trial.
2. Evidence generated (survey and reviews) will be considered by an expert panel (N=20-25) including expert clinicians and allied health professionals who care for people with HF using a modified Delphi approach. The panel will make recommendations on all aspects of the trial design.
3. A patient and carer panel of people with a recent hospitalisation (\<6 months) for HF will provide recommendations on trial endpoints. The patient-and-carer advisory group (PCAG) will also input into these discussions.

Conditions

Interventions

OTHER

Patient and carer panel using nominal group approach and thematic analysis

Patient and carer panel using nominal group approach and thematic analysis

Sponsors & Collaborators

  • Hull York Medical School

    collaborator UNKNOWN

  • University of Birmingham

    collaborator OTHER

  • Robertson Centre for Biostatistics University of Glasgow Glasgow G12 8QQ

    collaborator UNKNOWN

  • Hull University Teaching Hospitals NHS Trust

    lead OTHER_GOV

Principal Investigators

  • Joe Cuthbert, MBBS MD · Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Cottingham Road, Kingston-Upon-Hull, HU6 7RX

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-02
Primary Completion
2026-10-01
Completion
2026-10-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07281040 on ClinicalTrials.gov