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Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

NCT07279740 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-12-12

No results posted yet for this study

Summary

This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia

Conditions

  • Alzheimer s Disease
  • Alzheimer Dementia (AD)
  • Alzheimer Dementia
  • Alzheimer Disease
  • Apathy
  • Apathy in Dementia

Interventions

DEVICE

intermittent theta burst stimulation (iTBS)

iTBS is a form of repetitive transcranial magnetic simulation (rTMS), a non-invasive form of brain stimulation.

DRUG

Methylphenidate (MPH)

Participants will be on methylphenidate clinically prior to the trial

Sponsors & Collaborators

  • Alzheimer Society of Canada

    collaborator OTHER

  • Sunnybrook Research Institute

    collaborator OTHER

  • Brain Canada

    collaborator OTHER

  • Sunnybrook Health Sciences Centre

    lead OTHER

Principal Investigators

  • Krista Lanctot, PhD · Sunnybrook Research Institute

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-31
Primary Completion
2027-10-01
Completion
2027-10-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07279740 on ClinicalTrials.gov