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Central Haemodynamics and Pacing for AV Block

NCT07276490 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2026-03-09

No results posted yet for this study

Summary

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

Conditions

  • Atrioventricular Block
  • Pacing Therapy
  • Right Ventricular Pacing
  • Conduction System Pacing

Interventions

DEVICE

Right ventricular pacing

Pacemaker implantation with RV lead placement

DEVICE

Conduction system pacing

Pacemaker implantation with conduction system (LBBAP) lead placement

Sponsors & Collaborators

  • North Estonia Medical Centre

    collaborator OTHER

  • Tartu University Hospital

    collaborator OTHER

  • University of Tartu

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-28
Primary Completion
2027-06-01
Completion
2027-12-31

Countries

  • Estonia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07276490 on ClinicalTrials.gov