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EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)

NCT07267624 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 170

Last updated 2026-04-29

No results posted yet for this study

Summary

The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed ventilator-associated pneumonia, compared to standard diagnostic methods.

As secondary objectives, the investigators will study antibiotic management and overall antibiotic consumption, as well as escalation or de-escalation events. The investigators will study the potential clinical impact of using multiplex PCR to see if the length of stay in the intensive care unit is reduced, as well as the duration of mechanical ventilation.

Conditions

  • VAP - Ventilator Associated Pneumonia
  • Antibiotic
  • Antibiotic Stewardship
  • Antibiotic Prescribing for Acute Respiratory-tract Infections
  • Intensive Care (ICU)

Interventions

DEVICE

PCR multiplex BioFire Pneumonia plus

In the intervention arm, in addition to traditional cultures for identifying pathogens and their resistance, multiplex PCR will be performed on the patient's respiratory samples. Empirical antibiotic therapy will be directly adapted to the results of multiplex PCR according to the guidelines provided.

Sponsors & Collaborators

  • BioMérieux

    collaborator INDUSTRY

  • Hospital Fribourg, Switzerland

    collaborator UNKNOWN

  • Hôpital universitaire de Lausanne

    collaborator UNKNOWN

  • Hospital of Neuchâtel

    collaborator UNKNOWN

  • Centre Hospitalier du Centre du Valais

    collaborator OTHER

  • Hospital Lugano

    collaborator UNKNOWN

  • University Hospital, Geneva

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-05
Primary Completion
2027-05-31
Completion
2028-06-30
FDA Device
Yes

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07267624 on ClinicalTrials.gov