Shared Pathways Between Non-Alcoholic Fatty Liver Disease and Psoriatic Disease With Guselekumab Therapy
NCT07255781 · Status: WITHDRAWN · Type: OBSERVATIONAL
Last updated 2026-02-23
Summary
The goal of this research study is to better understand if there is an association between non-alcoholic fatty liver disease (NAFLD) and active psoriatic disease (PD), and to assess the effect of Guselkumab (a medication approved by the FDA instead of the standard of care to treat PD), for NAFLD patients who receive Guselkumab for their PD.
Conditions
- Psoriasis (PsO)
- PsA (Psoriatic Arthritis)
- NAFLD (Nonalcoholic Fatty Liver Disease)
Interventions
- DRUG
-
Guselkumab Prefilled Syringe [Tremfya]
This trial aims to recruit patients who have psoriatic disease, have evidence of fatty liver disease, and have a BMI over 25, who are planning to start Guselkumab(Tremfya) as recommended by their primary rheumatologist or dermatologist
Sponsors & Collaborators
-
Janssen Scientific Affairs, LLC
collaborator INDUSTRY -
University of California, San Diego
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-11-30
- Primary Completion
- 2025-11-30
- Completion
- 2025-11-30
- FDA Drug
- Yes
More Related Trials
-
Comparison of Liver Health in Psoriatic Arthritis Patients Using Anti-TNF or Anti-IL17 Treatments
NCT06918886 ·Status: NOT_YET_RECRUITING
-
Lifestyle Modification in Psoriatic Patients With Fatty Liver
NCT05125757 ·Status: UNKNOWN ·Phase: NA
-
Effect of LIK066 on Reduction of Fatty Content in Livers of Obese Patients
NCT03205150 ·Status: COMPLETED ·Phase: PHASE2
-
Guselkumab (Anti-IL 23 Monoclonal Antibody) for Alcohol Associated Liver Disease
NCT04736966 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
NCT06613698 ·Status: RECRUITING ·Phase: PHASE2
-
Safety, Tolerability, Pharmacokinetics and Activity of GS-9450 in Adults With Non-Alcoholic Steatohepatitis (NASH)
NCT00740610 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction
NCT05478603 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)
NCT04583423 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis
NCT03486912 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluating the Safety, Tolerability, and Efficacy of GS-9674 in Participants With Nonalcoholic Steatohepatitis (NASH)
NCT02854605 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate Seladelpar in Subjects With Nonalcoholic Steatohepatitis (NASH)
NCT03551522 ·Status: TERMINATED ·Phase: PHASE2
-
A Study on How Semaglutide Works on Early Stages of Scar Tissue in the Liver Assessed by Pictures of the Liver
NCT03357380 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, and Efficacy of GS-4997 Alone or in Combination With Simtuzumab (SIM) in Adults With Nonalcoholic Steatohepatitis (NASH) and Fibrosis Stages F2-F3
NCT02466516 ·Status: COMPLETED ·Phase: PHASE2
-
Pilot Study of Simtuzumab in the Treatment of Liver Fibrosis
NCT01452308 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
NCT07229911 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis
NCT03486899 ·Status: COMPLETED ·Phase: PHASE2
-
A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
NCT05395481 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
FibroScan ® Study: Assessing Liver Fibrosis in Patients Using Methotrexate for Psoriasis
NCT03820934 ·Status: WITHDRAWN ·Phase: NA
-
A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH
NCT07221227 ·Status: RECRUITING ·Phase: PHASE3
-
Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis
NCT03053050 ·Status: TERMINATED ·Phase: PHASE3
-
A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH
NCT04048135 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.
NCT05857644 ·Status: COMPLETED ·Phase: PHASE1
-
Different Doses of ZED1227 vs. Placebo in NAFLD
NCT05305599 ·Status: COMPLETED ·Phase: PHASE2
-
Simtuzumab (SIM, GS-6624) in the Treatment of Cirrhosis Due to NASH
NCT01672879 ·Status: TERMINATED ·Phase: PHASE2
-
Study in Healthy Adults Evaluating PF-07202954
NCT04857437 ·Status: COMPLETED ·Phase: PHASE1