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Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus

NCT07251608 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-11-26

No results posted yet for this study

Summary

The goal of this study is to learn about the safety of Niagen®Plus, an injectable form of nicotinamide riboside (NR), and to see how it affects levels of NAD+ in the blood. Niagen®Plus will be given either by subcutaneous (under the skin) or intramuscular (into the muscle) injection at two dose levels (50 mg or 100 mg).

The main questions this study aims to answer are:

Is Niagen®Plus safe and well-tolerated when given by injection several times over 100 days?

How do NAD+ levels in blood change after repeated doses of Niagen®Plus?

What are participants' and clinicians' experiences with the injections?

Researchers will also look at changes in fatigue, sleep, quality of life, inflammation markers, mitochondrial efficiency, and perceived skin appearance.

Participants will:

Receive three injections in clinic on Days 1-3, followed by a Day 10 follow-up visit

Self-inject Niagen®Plus at home three times per week from Days 10-100

Return to the clinic on Days 40 and 100 for safety and laboratory testing

Complete short surveys about fatigue, sleep, and overall well-being throughout the study

The study will include 40 generally healthy adults and will last about 100 days per participant.

Conditions

Interventions

DRUG

Niagen®Plus

Pharmaceutical-grade nicotinamide riboside chloride (NRCl), compounded for sterility and reconstituted in bacteriostatic water for injection. Administered by subcutaneous or intramuscular injection at 50 mg or 100 mg per dose. Participants receive three clinician-administered injections during clinic visits on Days 1-3, followed by at-home subcutaneous self-administration three times per week (Monday, Wednesday, Friday) from Days 10-100, depending on study arm.

Sponsors & Collaborators

  • ChromaDex, Inc.

    lead INDUSTRY

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2026-02-15
Completion
2026-02-15
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07251608 on ClinicalTrials.gov