Developing a Methodological Framework and a Dissemination Plan for Herb-drug Interactions-related Clinical Practice Guidelines

Summary

The goal of this observational study is to develop a methodological framework for clinical practice guidelines (CPGs) related to herb-drug interactions (HDIs). It will also learn barriers and facilitators of disseminating HDI-related CPGs and formulate a dissemination plan. The main questions it aims to answer are:

1. develop a methodological framework for HDI-related CPGs using a Delphi method;
2. identity barriers and facilitators of disseminating HDI-related CPGs through semi-structured interviews and formulate a theory-informed dissemination plan to promote the uptake of CPGs locally and internationally.

* Participants in the Delphi survey will engage in a consensus development to determine the framework of HDI-related CPGs, including key characteristics and components of this framework.
* Participants in the semi-structured interviews will be interviewed on the following topics: their experiences in searching for evidence and CPGs related to HDIs; barriers and facilitators encountered when obtaining information from existing CPGs; their views on the ideal platform for disseminating HDI-related CPGs.

Conditions

• Herb-drug Interactions

Interventions

OTHER

Delphi method survey

The Delphi survey intervention will comprise two rounds of structured questionnaire surveys to gather stakeholder consensus on the factors and components to consider when translating herb-drug interactions' evidence into recommendations. Following the first round of surveys, we will calculate the median score and interquartile range for each consideration factor, expressing participant consensus on these factors as percentages. Consideration factors achieving consensus in the first round will be considered for inclusion in the clinical practice guideline development framework. For factors where consensus was not reached, we will summarize relevant opinions and further evaluate them in the second round of the Delphi survey. Finally, descriptive statistics (frequencies and proportions) will be used to summarize the quantitative results of the Delphi survey.

OTHER

Semi-structured interview

A face-to-face semi-structured interview with participants will be conducted. Interview questions will be developed based on the Theoretical Domains Framework (TDF). The interview will cover three main aspects: a. participants' experiences in searching for evidence and clinical practice guidelines (CPGs) related to herb-drug interactions (HDIs); b. barriers and facilitators encountered when retrieving HDI-related CPGs or obtaining information from existing CPGs; c. their views on the ideal platform for disseminating HDI-related CPGs.

Sponsors & Collaborators

• Chinese Medicine Development Fund

  collaborator UNKNOWN

• Chinese Medicine Hospital, Hong Kong Baptist University

  collaborator UNKNOWN

• Hong Kong Poison Control Center, Hospital Authority

  collaborator UNKNOWN

• Memorial Sloan Kettering Cancer Center

  collaborator OTHER

• Chinese University of Hong Kong

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-02-01

Primary Completion

2026-06-30

Completion

2026-07-31

Countries

• Hong Kong

Study Locations