MedTrace Logo

Non-Invasive Diagnosis and Monitoring of Cardiac Masses by Liquid Biopsy

NCT07235865 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2026-04-15

No results posted yet for this study

Summary

This is a nonprofit, observational, prospective and retrospective,multicenter study in a population of young and adult patients ≥12 years with a diagnosis of a cardiac mass. The study will include both patients with masses of unknown pathological diagnosis and patients with a known histology of benign or malignant tumors. We predict a case-control allocation ratio of 1:1 between cardiac malignant tumors and benign lesions. Peripheral blood will be collected at participating centers during routine venipuncture,processed and then shipped for liquid biopsy ctDNA NGS analyses. If available, in malignant cases, matched tumor tissue samples collected as per clinical practice solid biopsies or surgery will be used for analyses. Longitudinal tracking through serial blood draws could be performed in selected cases of patients with cardiac malignancies who receive cancer treatment

Conditions

  • Cardiac Masses

Interventions

GENETIC

NGS-guided regimen: Regimen A

Liquid biopsy, consisting of a venous blood sample, will be collected during routine venipuncture

Sponsors & Collaborators

  • Niguarda Hospital

    lead OTHER

Principal Investigators

  • Katia Bencardino, MD · Niguarda Hospital

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-25
Primary Completion
2025-01-01
Completion
2026-12-25

Countries

  • Italy

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07235865 on ClinicalTrials.gov