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Timing of Opioid Administration and Postoperative Respiratory Depression.

NCT07227389 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2025-11-14

No results posted yet for this study

Summary

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids.

The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation.

A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation.

The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Conditions

  • Respiratory Complications
  • Opioid Induced Respiratory Depression
  • Postoperative Respiratory Complications

Interventions

DIAGNOSTIC_TEST

Respiratory volume monitoring

Noninvasive continuous respiratory monitoring utilizing bio-impedance to detect tidal volumes, respiratory rate, and minute ventilation.

Sponsors & Collaborators

  • Wayne State University

    lead OTHER

Principal Investigators

  • Wael Saasouh, MD · Wayne State University

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-31
Primary Completion
2028-12-01
Completion
2029-01-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07227389 on ClinicalTrials.gov