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An Exosomal miRNA-based Liquid Biopsy for ICC Detection

NCT07225452 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 535

Last updated 2026-03-13

No results posted yet for this study

Summary

Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need.

The LUMIC study aims to develop a non-invasive liquid biopsy platform based on both exosomal microRNAs (exo-miRNAs) to detect intrahepatic cholangiocarcinoma with high sensitivity and specificity.

Conditions

  • Intrahepatic Cholangiocarcinoma (Icc)

Interventions

DIAGNOSTIC_TEST

Small RNA sequencing

Small RNA sequencing of serum/plasma RNA to identify ICC-specific upregulated miRNAs

DIAGNOSTIC_TEST

LUMIC assay

RT-qPCR validation of selected miRNAs

Sponsors & Collaborators

  • City of Hope Medical Center

    lead OTHER

Principal Investigators

  • Ajay Goel, PhD · City of Hope Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-06-21
Primary Completion
2026-01-05
Completion
2026-02-05

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07225452 on ClinicalTrials.gov