Intravital Microscopy in Human Solid Tumors

Summary

This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Conditions

• Solid Tumor, Adult
• Clinical Stage IV Gastric Cancer AJCC v8
• Malignant Solid Neoplasm
• Metastatic Colorectal Carcinoma
• Metastatic Gastric Carcinoma
• Metastatic Primary Malignant Brain Neoplasm
• Metastatic Sarcoma
• Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8
• Resectable Colorectal Carcinoma
• Resectable Liver and Intrahepatic Bile Duct Carcinoma
• Resectable Pancreatic Carcinoma
• Resectable Sarcoma
• Stage IV Colorectal Cancer AJCC v8
• Anatomic Stage IV Breast Cancer AJCC v8
• Malignant Brain Neoplasm
• Metastatic Breast Carcinoma
• Metastatic Liver Carcinoma
• Metastatic Pancreatic Carcinoma
• Resectable Brain Neoplasm
• Resectable Breast Carcinoma
• Resectable Gastric Carcinoma
• Stage IV Hepatocellular Carcinoma AJCC v8
• Stage IV Pancreatic Cancer AJCC v8

Interventions

DEVICE

Diagnostic Microscopy

Undergo Intravital microscopy (IVM), which allows real-time, direct visualization of microscopic blood vessels and calculation of blood flow.

DRUG

Fluorescein Sodium Injection

Given IV as part of IVM procedure

Sponsors & Collaborators

• Mayo Clinic

  lead OTHER

Principal Investigators

• Emmanuel M Gabriel, M.D., Ph.D. · Mayo Clinic

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-28

Primary Completion

2026-09-30

Completion

2026-09-30

FDA Device

Yes

Countries

• United States

Study Locations