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Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study

NCT07222306 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-10-29

No results posted yet for this study

Summary

This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD. It builds on an ongoing study testing different combinations of THC and CBD in 200 veterans. In this project, up to 100 veterans will complete brain scans before and after 12 weeks of cannabis administration to see how the brain changes over time. The scans will measure a marker sensitive to neuroinflammatory state, brain communication, and activity during thinking and emotion tasks. By linking these brain changes to improvements in PTSD symptoms, suicidal thoughts, and quality of life, this study may help identify which veterans benefit most from cannabis-based treatments and support more personalized care for PTSD.

Conditions

  • PTSD
  • Suicidal Thoughts and Behaviors
  • PTSD Symptoms
  • Depressive Symptoms

Interventions

DRUG

1-(2-[+F]fluoroethyl)-L-tryptophan

1-(2-\[+F\]fluoroethyl)-L-tryptophan tracer will be used during PET imaging

Sponsors & Collaborators

  • Barbara Ann Karmanos Cancer Institute

    collaborator OTHER

  • Wayne State University

    lead OTHER

Principal Investigators

  • Eric Woodcock · Wayne State University

  • Hilary Marusak, PhD · Wayne State University

Eligibility

Min Age
19 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2030-08-31
Completion
2030-08-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07222306 on ClinicalTrials.gov