Role of ROS and cAMP-PKA Biomarkers in ADPKD
NCT07217158 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2025-10-27
Summary
The primary objective is to determine the prognostic value of markers of ROS and cAMP-PKA signaling to assess disease severity and progression in patients with ADPKD.
Conditions
- Autosomal Dominant Polycystic Kidney Disease
Sponsors & Collaborators
-
United States Department of Defense
collaborator FED - lead OTHER
Principal Investigators
-
Maria V. Irazabal, M.D., Ph.D. · Mayo Clinic
Eligibility
- Min Age
- 15 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-07-01
- Primary Completion
- 2027-03-31
- Completion
- 2027-06-30
Countries
- United States
Study Locations
More Related Trials
-
Tolvaptan Extension Study in Participants With ADPKD
NCT01214421 ·Status: COMPLETED ·Phase: PHASE3
-
Exercise Intolerance in Renal Failure
NCT01356966 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT06800651 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]
NCT01280721 ·Status: COMPLETED ·Phase: PHASE3
-
Paricalcitol Over Inflammatory Parameters on Chronical Kidney Disease Patients
NCT01820767 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Tamibarotene in Patients With ADPKD
NCT06289998 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Hydroxychloroquine in Cardiovascular Disease in Patients With Chronic Kidney Disease: A Proof of Concept Study
NCT01537315 ·Status: TERMINATED ·Phase: PHASE2
-
Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease
NCT06747572 ·Status: ACTIVE_NOT_RECRUITING
-
Effects of a Non-Calcium Based Phosphate Binder on FGF23 Levels in Chronic Kidney Disease
NCT01308242 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
NCT05521191 ·Status: COMPLETED ·Phase: PHASE1
-
The PRIMO II Study: Paricalcitol Injection Benefits in Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease (CKD) Stage 5
NCT00616902 ·Status: TERMINATED ·Phase: PHASE3
-
Feasibility of Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease
NCT05510115 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Clinical and Molecular Description of PKD1 and PKD2 Mutation Negative Carriers in ADPKD
NCT02112136 ·Status: COMPLETED ·Phase: NA
-
Somatostatin In Patients With Autosomal Dominant Polycystic Kidney Disease And Moderate To Severe Renal Insufficiency
NCT01377246 ·Status: COMPLETED ·Phase: PHASE3
-
Long Term Safety of Immediate-release Tolvaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease
NCT02251275 ·Status: COMPLETED ·Phase: PHASE3
-
Inflammatory and Immune Profiling of Kidney Tissue Obtained From Patients With Newly Diagnosed Kidney Disease
NCT01156428 ·Status: COMPLETED
-
Pilot Study of Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT00286156 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD): The Role of Biomarkers in Predicting a Response to Therapy
NCT00920309 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure
NCT02511418 ·Status: COMPLETED ·Phase: NA
-
Bempedoic Acid Therapy for Polycystic Kidney Disease
NCT07282821 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Effect of Phosphate Binders on Markers of Vascular Health in Chronic Kidney Disease Stages 3 and 4
NCT01277497 ·Status: TERMINATED ·Phase: PHASE4
-
Targeting FMO-Mediated TMAO Formation in Kidney Disease (TMAO) Study
NCT03152097 ·Status: COMPLETED ·Phase: NA
-
A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) [Extension of Study 156-05-002]
NCT01022424 ·Status: COMPLETED ·Phase: PHASE3
-
ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT06902558 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease
NCT06350123 ·Status: COMPLETED ·Phase: PHASE2