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Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

NCT07213752 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2025-10-09

No results posted yet for this study

Summary

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Conditions

  • Periodontitis
  • Periodontitis Stage III
  • Periodontal Disease
  • Diode Laser Therapy
  • Smoking
  • Malondialdehyde

Interventions

DEVICE

Diode Laser Application in Deep Periodontal Pockets

A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.

PROCEDURE

Professional Mechanical Plaque Removal

Professional mechanical removal of supragingival plaque and calculus

PROCEDURE

Scaling and Root Planing

Subgingival scaling and root planing

Sponsors & Collaborators

  • Selcuk University Scientific Research Projects Unit

    collaborator UNKNOWN

  • The Scientific and Technological Research Council of Turkey

    collaborator OTHER

  • Selcuk University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-12-10
Primary Completion
2025-01-21
Completion
2025-06-05
FDA Device
Yes

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07213752 on ClinicalTrials.gov