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Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

NCT07210411 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-03-09

No results posted yet for this study

Summary

The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \& cardiovascular function in participants with spinal cord injury.

Conditions

  • Spinal Cord Injuries

Interventions

DIAGNOSTIC_TEST

Tests of sympathetic inhibition

Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.

DIAGNOSTIC_TEST

Tests of above level sympathetic activation

Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).

DIAGNOSTIC_TEST

Testing of below level sympathetic activation

Cold pressor test of the foot and bladder pressor response (in individuals with SCI) will be tested.

DEVICE

Epidural stimulation

Currently implanted epidural stimulation will be used during diagnostic testing.

DEVICE

Transcutaneous stimulation

Transcutaneous stimulation will be used for participants with spinal cord injury without an implanted stimulator during diagnostic testing.

Sponsors & Collaborators

Principal Investigators

  • Ryan Solinsky, MD · Mayo Clinic

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-05
Primary Completion
2030-12-31
Completion
2031-04-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07210411 on ClinicalTrials.gov