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The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch

NCT07203274 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-04-23

No results posted yet for this study

Summary

It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pain and itching. The substances delgocitinib and lidocaine have both been shown to relieve various types of pain. We therefore assume that these creams will be also able to relieve itching. The purpose of this trial experiment is therefore to investigate the effect of delgocitinib, lidocaine and their combination on experimentally induced itching.

Conditions

  • Itchiness

Interventions

DRUG

Delgocitinib cream

Delgocitinib cream

DRUG

lidocaine cream

Lidocaine cream

COMBINATION_PRODUCT

Lidocaine+Delgocitinib

The two cream will me mixed togheter

DRUG

Vehicle (placebo)

Vehicle Cream

OTHER

Histamine Dihydrochloride (HDC)

One drop of histamine will be applied on the selected areas and pierced with a lancet

OTHER

Cowhage (Mucuna Pruriens)

About 30 spicules will be applied on the selected areas and inserted manually

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07203274 on ClinicalTrials.gov